Avastin dosing in first-line advanced nsNSCLC
Paz Ares explained, SCLC is a transcription-addicted tumor driven by dysregulated expression of several key transcription factors. Lurbinectedin upsets these processes by binding to gene promoter regions, creating DNA breaks, and inhibiting transcription, ultimately downregulating the expression of growth-promoting proteins. Among the patients included in the trial, the objective response rate ORR to lurbinectedin was Of note, 5 of 8 patients who failed prior immunotherapy demonstrated a response to lurbinectedin.
Subgroup analyses revealed that lurbinectedin conferred activity regardless of whether patients had platinum-sensitive or platinum-resistant disease Fig.
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The median PFS with lurbinectedin monotherapy was 3. Lurbinectedin appeared to be relatively well tolerated, with a manageable safety profile. The most common all-grade TRAEs included fatigue Few patients discontinued treatment due to adverse events 1. Anna F.
Lung Cancer Research Highlights from the 12222 ASCO Annual Meeting
Paz Ares remarked. Farago affirmed that lurbinectedin edges out topotecan based on historical efficacy data given numerically better ORR and OS findings. Although lurbinectedin has received an Orphan Drug Designation by the U. Farago feels it will be important to see phase III data for the agent. References 1. Phase II trial of neoadjuvant bevacizumab plus chemotherapy and adjuvant bevacizumab in patients with resectable nonsquamous non-small-cell lung cancers.
Your use of third-party websites is at your own risk and subject to the terms and conditions of use for such sites. Lung Cancer: Avastin Dosing and Usage. Do not administer Avastin for at least 28 days after surgery and until the wound is fully healed Discontinue in patients with wound healing complications requiring medical intervention Hemorrhage Severe or fatal hemorrhage have occurred Do not administer Avastin to patients with serious hemorrhage or recent history of hemoptysis Discontinue for Grade hemorrhage.
Important treatment considerations—Women of childbearing potential Avastin increases the risk of ovarian failure and may impair fertility.
Inform females of reproductive potential of the risk of ovarian failure prior to the first dose of Avastin Long-term effects of Avastin exposure on fertility are unknown Patients should also use effective contraception during treatment and for 6 months following the last dose of Avastin Nursing mothers should not breastfeed during treatment and for 6 months following their last dose of treatment.
Dose modifications for adverse reactions. Continuation maintenance Use of at least 1 of the agents given in first line, beyond 4—6 cycles, in the absence of disease progression.
View Avastin dosing across all approved cancer types. Do not administer Avastin for at least 28 days after surgery and until the wound is fully healed Discontinue in patients with wound healing complications requiring medical intervention Hemorrhage Severe or fatal hemorrhage, including hemoptysis, GI bleeding, hematemesis, central nervous system hemorrhage, epistaxis, and vaginal bleeding, occurred up to 5-fold more frequently in patients receiving Avastin.
Pregnancy warning Based on the mechanism of action and animal studies, Avastin may cause fetal harm Advise female patients that Avastin may cause fetal harm, and to inform their healthcare provider of a known or suspected pregnancy Advise females of reproductive potential to use effective contraception during treatment with Avastin and for 6 months after the last dose of Avastin Advise nursing women not to breastfeed during treatment with Avastin and for 6 months following their last dose of treatment Avastin may impair fertility.
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Lung Cancer Research Highlights from the ASCO Annual Meeting | IASLC Lung Cancer News
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